Synthesis and antimicrobial activity of 2-substituted [4-(1, 3, 4-oxadiazol-2-yl methyl)] phthalazin-1 (2H)-one derivatives

Ajjanna, M.S. and Venugopal, K.R. and Jathi Keshavayya, . and Palusa Sanath Kumar, G. and Somashekar, B.C. and Prosenjit Bose, . and Peethambar,, S.K. and Satish Kumar, G. (2010) Synthesis and antimicrobial activity of 2-substituted [4-(1, 3, 4-oxadiazol-2-yl methyl)] phthalazin-1 (2H)-one derivatives. European journal of medicinal chemistry, 45 (11). pp. 4983-4989.

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Official URL: http://10.1016/j.ejmech.2010.08.005

Abstract

A series of new 2-substituted [4-(1,3,4-oxadiazol-2-yl)methyl]phthalazin-1(2H)-one derivatives 7a-h to 9a-h were designed and synthesized from methyl (4-oxo-3,4-dihydrophthalazin-1-yl)acetate (4), which in was turn prepared from phthalic anhydride. The structure of synthesized new compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains. Several of these compounds showed antimicrobial activity.

Item Type: Article
Subjects: Faculty of Engineering > Computer Science & Information Science Engineering
Divisions: University Visvesvarayya College of Engineering > Department of Computer Science and Information Science Engineering
Depositing User: Ms Laxmi Kamble
Date Deposited: 15 Sep 2021 05:42
Last Modified: 15 Sep 2021 05:42
URI: http://eprints-bangaloreuniversity.in/id/eprint/9507

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