Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol-Induced Myocardial Oxidative Stress in Rats

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Anupama Sindhaghatta Kariyappa, . and Sowbhagya Ramachandregowda, . and Santosh Anand, . and Sowbhagya Ramachandregowda, . and Bhagyalakshmi Dundaiah, . and Mamatha Madhugiri Gopinath, . and Ravikiran Tekupalli, . (2019) Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol-Induced Myocardial Oxidative Stress in Rats. Pharmacognosy Magazine, 15 (64S). pp. 320-327. ISSN 0973-1296

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Abstract

Background: Decalepis hamiltonii (Dh), a climbing shrub belonging to the family Apocynaceae, is consumed for its health-promoting properties. Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region-specific responses against isoproterenol (ISO)-induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4-hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO-treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO-administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO-induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO-induced MI in rats.

Item Type: Article
Uncontrolled Keywords: : Decalepis hamiltonii, isoproterenol, myocardial infarction, oxidative stress, serum lipid profile
Subjects: Faculty of Science > Environmental and Biological Sciences > Microbiology & Biotechnology
Faculty of Science > Environmental and Biological Sciences
Divisions: Jnana Bharathi / Central College Campus > Department of Microbiology and Biotechnology
Depositing User: Madhu C C
Date Deposited: 30 Sep 2020 09:40
Last Modified: 30 Sep 2020 09:40
URI: http://eprints-bangaloreuniversity.in/id/eprint/9133

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