Solid phase synthesis of the protected peptide sequence (12-​16) of human fibrinopeptide A

Baligidad, S.K and Sivanandaiah, K.M. (1976) Solid phase synthesis of the protected peptide sequence (12-​16) of human fibrinopeptide A. Vignana Bharathi (Vignana Bharati Bangalore University journal of science), 2 (2). pp. 72-6. ISSN 0377-8487

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Abstract

The title H-​Gly-​Gly-​Gly-​Arg(NO2)​-​OMe (I) was prepd. by a solid-​phase method in which both Me3CO2C (BOC) and o-​O2NC6H4S (Nps) amino acids were used. R-​Gly-​Gly-​Gly-​Arg(NO2)​-​resin (R = BOC, Nps) were prepd. and cleaved with MeOH and Et3N to give R-​Gly-​Gly-​Gly-​Arg(NO2)​-​OMe (II) in yields of 52.5​% for R = BOC and 36​% for R = Nps. II was deprotected with HCl to give I.

Item Type: Article
Subjects: Faculty of Science > Pure Sciences > Chemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Chemistry
Depositing User: Ms. Deepa M Kolli
Date Deposited: 22 Sep 2016 09:09
Last Modified: 22 Sep 2016 09:09
URI: http://eprints-bangaloreuniversity.in/id/eprint/5955

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