Age-​related changes in cardiac muscle of rat

Radha, E. and Mohan, S. (1980) Age-​related changes in cardiac muscle of rat. Advances in Myocardiology, 2. pp. 225-231. ISSN 0270-4056

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Study of the age-​related changes in cardiac muscle of 5-​25-​mo-​old rats showed that the muscle mass decreased by 10​% whereas the ratio of the wt. of cardiac muscle to body wt. decreased by 30​% between 5 and 25 mo. Autolytic and proteolytic activity of sarcoplasmic proteins increased remarkably (70​% and 200​%, resp.) between 5 and 25 mo of age. Although the total protein content decreased, the amt. of fibrous protein (collagen) increased by 50​%. Levels of salt-​sol. and labile collagen (free hydroxyproline released at 65° in Ringer soln.) decreased by 65​% and 50​%, resp. Whereas insol. collagen increased by 180​% with advance in age from 5 to 25 mo. Increase in acid sol. collagen was seen only ≤20 mo of age. The acid mucopolysaccharide content decreased, whereas the activity of β-​glucuronidase showed an increase from 110-​148 units between 10 and 15 mo of age. β-​N-​Acetylglucosaminidase increased by 25​% as the age increased from 5 to 25 mo.

Item Type: Article
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Ms. Sathyavathi N
Date Deposited: 10 Sep 2016 07:36
Last Modified: 10 Sep 2016 07:36

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