Heart lactate dehydrogenase isoenzymes as a function of age, exercise and experimental necrosis

Asha Devi, S. (1988) Heart lactate dehydrogenase isoenzymes as a function of age, exercise and experimental necrosis. Indian Journal of Experimental Biology, 26 (8). pp. 628-632. ISSN 0019-5189

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/3198163

Abstract

The effect of phys. training on heart lactate dehydrogenase (LDH) isoenzymes was studied in young and old rats with exptl. necrosis. A decrease in H4 activity was seen in the necrotic hearts of both young and old sedentary rats. As compared with the normal hearts (Sed-​Cont)​, trained hypertrophic and ischemic hearts showed a shift in isoenzymes towards the synthesis of M-​LDH only in the young and not in the old. These changes were accompanied by corresponding depletions in the total LDH activity in the necrotic hearts as compared to the Sed-​Cont. Changes in isoenzyme activities were accompanied by corresponding changes in the heart morphol. Exercise also reduced the mortality related with exptl. myocardial infarction, the effect being more significant in the young. Changes in H-​LDH and M-​LDH are interpreted in terms of O insufficiency in the heart muscle. The effect of exercise on the heart was age-​specific.

Item Type: Article
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Mr . Chandrashekar
Date Deposited: 10 Sep 2016 07:17
Last Modified: 10 Sep 2016 07:17
URI: http://eprints-bangaloreuniversity.in/id/eprint/5572

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