Synthetic peptides related to laminin pentapeptide (YIGSR) fragment

Sivanandaiah, K.M. and Sureshbabu, V.V. and Shankaramma, S.C. and Lakshmana, M. and Babu, R. and Arif, M.A. and Kumar, M. (1996) Synthetic peptides related to laminin pentapeptide (YIGSR) fragment. Indian Journal of Experimental Biology, 34 (7). pp. 658-662. ISSN 0975-1009

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The synthetic laminin pentapeptide amide fragment (LF), Tyr-Ile-Gly-Ser-Arg-NH2 corresponding to a part of B1 chain of the glycoprotein, laminin, and six of its analogues having structural modifications at positions 1, 3 and 4 were synthesized by solid phase method employing mainly 9-fluorenylmethoxycarbonyl-amino acid trichlorophenyl esters as coupling agents and Merrifield resin as the solid support. Their biological activities were studied in vivo by lung tumor colonization assay and in vitro by cell adhesion assay. The activity of synthetic LF was found to correlate with the earlier reported results in both in vivo and in vitro assays. Among the analogues made, Tyr4 LF and Thr4LF were found to inhibit the lung tumor colonies more efficiently than LF itself in the in vivo assay whereas D- Ser4LF exhibited almost the same inhibition as LF.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: antineoplastic agent; laminin; oligopeptide; peptide; tyrosyl isoleucyl glycyl seryl arginine; tyrosyl-isoleucyl-glycyl-seryl-arginine, animal; article; C57BL mouse; chemistry; comparative study; mouse, Animals; Antineoplastic Agents; Laminin; Mice; Mice, Inbred C57BL; Oligopeptides; Peptides
Subjects: Faculty of Science > Pure Sciences > Chemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Chemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 03 Feb 2016 09:40
Last Modified: 26 Sep 2016 11:04

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