Chlorpyrifos Induced Region Specific Vulnerability in Rat CNS and Modulation by Age and Cold Stress: An Interactive Study

Downloads

Downloads per month over past year

Mahaboob Basha, P. and Annappa Poojary, . (2011) Chlorpyrifos Induced Region Specific Vulnerability in Rat CNS and Modulation by Age and Cold Stress: An Interactive Study. Neurochemical Research, 36 (2). pp. 241-249. ISSN 0364-3190

[img]
Preview
Text
mahaboob.pdf - Published Version

Download (512kB) | Preview
Official URL: https://doi.org/10.1007/s11064-010-0311-3

Abstract

Chlorpyrifos (CPF)​, an organophosphorus insecticide is known to cause ill health in non-​target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-​related differences and vulnerability in central nervous system of rats. The results indicated an interaction with age and cold exposure resulting in marked decreased activity levels of SOD (P < 0.05)​, CAT (P < 0.05)​, GPx (P < 0.05)​, GST (P < 0.05) followed by increased MDA (P < 0.05) and decreased GSH levels (P < 0.05)​. The ANOVA and Post-​hoc anal. showed that antioxidant enzymes decreased significantly (P < 0.05) on CPF exposure. Moreover synergistic action of CPF and cold stress at 15°C caused higher inhibition on comparison with CPF and cold stress alone and together at 20°C indicating the extent of peroxidative damage in discrete regions of CNS. Further this study showed young individuals to be more sensitive than adults.

Item Type: Article
Uncontrolled Keywords: Chlorpyrifos Cold stress Oxidative stress Regional changes Interactive effects In
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Mr . Chandrashekar
Date Deposited: 30 Aug 2016 09:33
Last Modified: 30 Aug 2016 09:33
URI: http://eprints-bangaloreuniversity.in/id/eprint/5142

Actions (login required)

View Item View Item