Oxidative stress products in type 2 diabetes and their relation to paraoxonase 1 activity

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Ali Abdulqaw, . and Ahmed Qahtan, . and Manjunath, N.H. (2011) Oxidative stress products in type 2 diabetes and their relation to paraoxonase 1 activity. Bioscan, 6 (3). pp. 487-491. ISSN 0973-7049

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Abstract

The present study indicated a significant increase in the serum advanced oxidn. protein products (AOPP) and malondialdehyde (MDA) a marker of lipid peroxidn., in diabetic group compared to control group. AOPP was found to be pos. correlated with MDA and Glycated Hb [HbA1c]​. AOPP was neg. correlated with Paraoxonase- 1 (PON1) and this correlation was statistically not significant. PON1 activity was found to be decreased in diabetic group compared to control. Neg. correlation was found between PON1 activity and MDA, HbA1c and with diabetic period. There was no correlation found between AOPP and diabetic period. On other hand, MDA level was pos. correlated with HbA1c and diabetic period. The studies also indicated that there is no difference in the level of AOPP, MDA and PON1 between vegetarian and non-​vegetarian subjects. The neg. correlation between PON1 level with the levels of MDA, AOPP, HbA1c, and diabetic period indicates the role of PON1 enzyme in oxidative stress. The pos. correlation between the levels of MDA and AOPP supports the coupling process of lipid and protein oxidn.

Item Type: Article
Uncontrolled Keywords: Type 2 diabetes Paraoxonase 1 Oxidative stress products Advanced oxidation protein products Malondialdehyde
Subjects: Faculty of Science > Environmental and Biological Sciences > Biochemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Biochemistry
Depositing User: Mr. Lokeshareddy Y C
Date Deposited: 01 Sep 2016 07:09
Last Modified: 01 Sep 2016 07:09
URI: http://eprints-bangaloreuniversity.in/id/eprint/5136

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