Synthesis, characterization and pharmacological evaluation of palmitic acid derivatives of salicylic acid and anthranilic acid

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Saqib Asma, . and Karigar Chandrakant, S. and Pasha Mohammed Afzal, . and Harish Metticule Rao, S. (2012) Synthesis, characterization and pharmacological evaluation of palmitic acid derivatives of salicylic acid and anthranilic acid. Journal of Pharmaceutical Research and Opinion, 2 (4). pp. 35-38. ISSN 2249-1953

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Abstract

In the present study, salicylic acid and anthranilic acid were modified as lipids palmitoylsalicylic acid (PSA) and N-​palmitoylanthranilic acid (N-​PAA) by a simple esterification​/amidation reaction of the resp. acid with palmitoyl chloride. On screening for the pharmacol. activity, PSA exhibited potent and persistent analgesic and antiinflammatory effects, while N-​PAA, demonstrated novel analgesic and antipyretic effects.

Item Type: Article
Uncontrolled Keywords: : Aspirin, Palalmitoyl salicylic acid(PSA) , N - palmitoyl anthranilic acid (N-PAA),Cyclooxygenase, Lipooxygenase
Subjects: Faculty of Science > Environmental and Biological Sciences > Biochemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Biochemistry
Depositing User: Ms. Rekha Jadhav
Date Deposited: 30 Aug 2016 06:29
Last Modified: 30 Aug 2016 06:29
URI: http://eprints-bangaloreuniversity.in/id/eprint/4979

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