Age-​related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

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Ravikiran, . and Tekupall, . and Sowbhagya, . and Ramachandregowda, . and Anupama, . and Kariyappa, S. and Anand, . and Santosh, . and Bhagyalakshm, . and Dundaiah, . (2016) Age-​related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise. Molecular and Cellular Biochemistry, 419 (2). pp. 103-113. ISSN 0300-8177

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Official URL: https://doi.org/10.1007/s11010-016-2754-6

Abstract

The synergistic effects of phys. exercise and diet have profound benefits on brain function. The present study was aimed to det. the effects of exercise and Decalepis hamiltonii (Dh) on age-​related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 mo old were orally supplemented with Dh ext. and swim trained at 3 % intensity for 30 min​/day, 5 days​/wk, for a period of 30 days. Supplementation of 100 mg Dh aq. ext.​/kg body wt. and its combination with exercise significantly elevated the antioxidant enzyme activities irresp. of age. Age-​related and region-​specific changes were obsd. in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-​T(+100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidn. in the rat brain

Item Type: Article
Uncontrolled Keywords: Decalepis hamiltonii Swimming training Antioxidant enzymes Oxidative markers
Subjects: Faculty of Science > Environmental and Biological Sciences > Microbiology & Biotechnology
Divisions: Jnana Bharathi / Central College Campus > Department of Microbiology and Biotechnology
Depositing User: Mr . Chandrashekar
Date Deposited: 23 Aug 2016 05:49
Last Modified: 23 Aug 2016 05:49
URI: http://eprints-bangaloreuniversity.in/id/eprint/4721

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