Methyl parathion induced regional alterations in the regulatory proteins during critical stage of central nervous system development in albino rat pups

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Nayeemunnisa, . and Begum, S. (1992) Methyl parathion induced regional alterations in the regulatory proteins during critical stage of central nervous system development in albino rat pups. Indian Journal of Physiology and Pharmacology, 36 (2). pp. 77-82. ISSN 00195499

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Official URL: http://www.ijpp.com/IJPP%20archives/1992_36_2/1992...

Abstract

Sublethal doses of methyl parathion (O,O-dimethyl-O-nitropbenyl-thiophosphate) injected intraperitoneally to IS and 21 day old rat pups induced regional alterations in the central nervous system (CNS) in the levels of total RNA, total proteins, modulatory protein Calmodulin (CaM), in the activity levels of memberane bound enzyme Cal•• ATPase and phospholipids. Levels of RNA and tOtal proteins increased considerably in IS days old methyl parathion treated (MPT) rat pups. Contrary to this the RNA lIIId total protein content exhibited remarkable decrease in 21 d.y old melthyl parathion treated animah. Calmodulin level showed an increase in cerebn.1 cortex and brain stern and decrease in cerebellum and spinal cord in IS day old methyl parathion treated rat pups. Whereas the level of Calmodulin decreased in cerebral cortex and cerebellum and increased in brain stem and spinal cord in 21 day ·old methyl parathion treated rat pups. Activity levels of calcium dependent ATPase showed significant inhibition in all the regions of Central Nervous System (CNS) of IS and 21 day old methyl parathion treated rat pups. Phospholipids showed a general increase in all the regions of Central Nervous System on methyl parathion exposure. In the light of these observations, it has been suggested that the molecular regulatory mechanisms involving Ca"/CaM are rendered inefficieilt due to toxic impact of methyl parathion.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adenosine triphosphatase (calcium); calmodulin; parathion methyl; phospholipid; protein; rna, animal experiment; article; brain cortex; brain stem; central nervous system; cerebellum; controlled study; enzyme inhibition; neurotransmitter release; newborn; nonhuman; rat; spinal cord, Animal; Brain; Brain Stem; Ca(2+)-Transporting ATPase; Calmodulin; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Injections, Intraperitoneal; Methyl Parathion; Phospholipids; Proteins; Rats; RNA; Spinal Cord
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Mr. Kirana Kumar D
Date Deposited: 02 Feb 2016 08:10
Last Modified: 02 Feb 2016 08:10
URI: http://eprints-bangaloreuniversity.in/id/eprint/437

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