Transfer hydrogenation; a convenient method for removal of some commonly used protecting groups in peptide synthesis

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Anantharamaiah, G.M. and Sivanandaiah, K.M. (1977) Transfer hydrogenation; a convenient method for removal of some commonly used protecting groups in peptide synthesis. Journal of the Chemical Society, Perkin Transactions 1 (5). pp. 490-491. ISSN 1472-7781

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Official URL: https://doi.org/10.1039/P19770000490

Abstract

N-Benzyloxycarbonyl and benzyl ester groups in peptidescan be conveniently removed by transfer hydrogenation with cyclohexene and 10% palladium-carbon catalyst. If freshly prepared palladium black catalyst is used, other commonly used protecting groups like Nτ-benzyl (histidine), benzyl ether (tyrosine, serine), and nitro (arginine) can also be removed much more rapidly than in the case of the usually employed catalytic hydrogenation.

Item Type: Article
Additional Information: cited By 27
Uncontrolled Keywords: benzyl derivative; ester; peptide, article; hydrogenation; synthesis, Benzyl Compounds; Esters; Hydrogenation; Peptides
Subjects: Faculty of Science > Pure Sciences > Chemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Chemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 25 Jan 2016 05:51
Last Modified: 16 May 2016 09:17
URI: http://eprints-bangaloreuniversity.in/id/eprint/41

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