Evaluation of some pharmacological activities of budmunchiamine - A isolated from Albizia amara


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Thippeswamy, S. and Mohana, D.C. and Abhishek, R.U. and Manjunath, K. (2015) Evaluation of some pharmacological activities of budmunchiamine - A isolated from Albizia amara. Brazilian Journal of Microbiology, 46 (1). pp. 139-143. ISSN 1678-4405


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Official URL: https://doi.org/10.1590/S1517-838246120131137


The present investigations were aimed to evaluate the antimicrobial and antioxidant efficacies of budmunchiamine-A (BUA) of Albizia amara. The activity-guided isolation leaded to isolate the bioactive compound budmunchiamine-A from alkaloid extract of A. amara. The budmunchiamine-A showed significant broad-spectrum antimicrobial activity with zone of inhibition (ZOI), minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values varied from 7.3 to 24.5 mm, 0.95 to 62.5 μg/mL, and 1.9 to 250 μg/mL, respectively. The budmunchiamine-A exhibited moderate antioxidant activity with inhibitory concentration 50 (IC <inf>50</inf>) value of 400 μg/mL in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and percent inhibition of β-carotene/linoleic acid was 67.8. The results suggest the possible use of budmunchiamine-A as a molecular entity for drug development in pharmaceutical industry. © 2015, Sociedade Brasileira de Microbiologia.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Albizia
Subjects: Faculty of Science > Environmental and Biological Sciences > Microbiology & Biotechnology
Divisions: Jnana Bharathi / Central College Campus > Department of Microbiology and Biotechnology
Depositing User: Mr. Kirana Kumar D
Date Deposited: 02 Apr 2016 07:17
Last Modified: 02 Apr 2016 07:17
URI: http://eprints-bangaloreuniversity.in/id/eprint/3351

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