Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors

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Baburajeev, C.P. and Dhananjaya Mohan, C. and Ananda, H. and Rangappa, S. and Fuchs, J.E. and Jagadish, S. and Sivaraman Siveen, K. and Chinnathambi, A. and Ali Alharbi, S. and Zayed, M.E. and Zhang, J. and Li, F. and Sethi, G. and Girish, K.S. and Bender, A. and Basappaa, . and Rangappa, K.S. (2015) Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors. Scientific Reports, 5. ISSN 20452322

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Official URL: https://doi.org/10.1038/srep14195

Abstract

Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient "green" catalyst strategy and identified as effective inhibitors of PTP1B in vitro. The lead compound, 6-(2-benzylphenyl)-3-phenyl-1,2,4triazolo31,3,4thiadiazole (BPTT) was most effective against human hepatoma cells, inhibits cell invasion, and decreases neovasculature in HUVEC and also tumor volume in EAT mouse models. This report describes an experimentally unidentified class of condensed-bicyclic triazolo-thiadiazoles targeting PTP1B and its analogs could be the therapeutic drug-seeds.

Item Type: Article
Additional Information: cited By 0
Subjects: Faculty of Science > Pure Sciences > Chemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Chemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 20 Apr 2016 11:18
Last Modified: 20 Apr 2016 11:18
URI: http://eprints-bangaloreuniversity.in/id/eprint/3248

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