A double hit model for the distribution of time to AIDS onset


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Chillale, N.R. (2013) A double hit model for the distribution of time to AIDS onset. In: A double hit model for the distribution of time to AIDS onset, 5–7 February 2013, Kuala Lumpur, Malaysia.

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Official URL: https://doi.org/10.1063/1.4823886


Incubation time is a key epidemiologic descriptor of an infectious disease. In the case of HIV infection this is a random variable and is probably the longest one. The probability distribution of incubation time is the major determinant of the relation between the incidences of HIV infection and its manifestation to Aids. This is also one of the key factors used for accurate estimation of AIDS incidence in a region. The present article i) briefly reviews the work done, points out uncertainties in estimation of AIDS onset time and stresses the need for its precise estimation, ii) highlights some of the modelling features of onset distribution including immune failure mechanism, and iii) proposes a 'Double Hit' model for the distribution of time to AIDS onset in the cases of (a) independent and (b) dependent time variables of the two markers and examined the applicability of a few standard probability models. © 2013 AIP Publishing LLC.

Item Type: Conference or Workshop Item (Paper)
Additional Information: cited By 0; Conference of International Conference on Mathematical Sciences and Statistics 2013, ICMSS 2013 ; Conference Date: 5 February 2013 Through 7 February 2013
Subjects: Faculty of Science > Applied Sciences > Statistics
Divisions: Jnana Bharathi / Central College Campus > Department of Statistics
Depositing User: Mr. Kirana Kumar D
Date Deposited: 05 Apr 2016 11:12
Last Modified: 05 Apr 2016 11:12
URI: http://eprints-bangaloreuniversity.in/id/eprint/2864

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