Oxidative macromolecular alterations in the rat central nervous system in response to experimentally co-induced chlorpyrifos and cold stress: A comparative assessment in aging rats

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Basha, P.M. and Poojary, A. (2012) Oxidative macromolecular alterations in the rat central nervous system in response to experimentally co-induced chlorpyrifos and cold stress: A comparative assessment in aging rats. Neurochemical Research, 37 (2). pp. 335-348. ISSN 1573-6903

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Official URL: https://doi.org/10.1007/s11064-011-0617-9

Abstract

Reactive oxygen species are generated as a result of a number of physiological and pathological processes which can promote multiple forms of oxidative damage including protein oxidation, and thereby influence the function of a diverse array of cellular processes. In our previous study we have reported that co-exposure to chlorpyrifos and cold stress in aging rats markedly influence the toxic outcome as a result of oxidative stress. In the present study, key neurochemical/enzymes were measured in order to evaluate the macromolecular alterations in response to experimentally co-induced chlorpyrifos and cold stress (15 and 20°C) either concurrently or individually in vivo for 48 h in discrete regions of brain and spinal cord of different age group rats. CPF and cold stress exposure either individually or in combination substantially increased the activity/levels of protein carbonyls, AST, ALT and decreased protein thiols, DNA, RNA and total proteins in discrete regions of CNS. Overall, the effects of co-exposure were appreciably different from either of the exposures. However, synergistic-action of CPF and cold stress at 15°C showed higher dyshomeostasis in comparison with CPF and cold stress alone and together at 20°C indicating the extent of oxidative macromolecular damage in discrete regions of brain and spinal cord. Furthermore, the present study demonstrates that macromolecular oxidative damage is highly pronounced in neonates and juveniles than the young adults. © 2011 Springer Science+Business Media, LLC.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: alanine aminotransferase; aspartate aminotransferase; carbonyl derivative; chlorpyrifos; DNA; RNA, aging; animal experiment; animal model; article; brain damage; brain size; central nervous system; cold stress; controlled study; down regulation; enzyme activity; homeostasis; in vivo study; macromolecule; male; newborn; nonhuman; oxidative stress; priority journal; protein localization; protein metabolism; rat; spinal cord lesion; upregulation; weight reduction, Aging; Animals; Central Nervous System; Chlorpyrifos; Cholinesterase Inhibitors; Cold Temperature; Male; Oxidation-Reduction; Rats; Rats, Wistar; Stress, Physiological, Rattus
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Mr. Kirana Kumar D
Date Deposited: 05 Apr 2016 05:59
Last Modified: 05 Apr 2016 05:59
URI: http://eprints-bangaloreuniversity.in/id/eprint/2784

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