Synthesis of palmitic acid derivatives of p-aminophenol and p-amino benzoic acid with improved pharmacodynamic profiles

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Saqib, A. and Pasha, M.A. and Karigar, C. and Harish, M.S.N.R. (2010) Synthesis of palmitic acid derivatives of p-aminophenol and p-amino benzoic acid with improved pharmacodynamic profiles. Acta Pharmaceutica Sciencia, 52 (2). pp. 205-212. ISSN 13072080

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Abstract

In the present study, p-amino phenol (PAP) and p-amino benzoic acid (PABA) have been modified as lipids palmitoyl p-amino phenol (PPAP) and palmitoyl N - p-amino benzoic acid (N-PPABA) by a simple amide formation reaction of the respective compounds with palmitoyl chloride. On screening PPAP and N-PPABA for pharmacological activity, PPAP (an analogue of paracetamol) has been found to exhibit potent and persistent analgesic and inflammatory activity than paracetamol. Whereas N-PPABA, an amide of p-amino benzoic acid demonstrated novel analgesic, antiinflammatory and antipyretic effects.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: 4 aminobenzoic acid; 4 aminophenol; 4 palmitoylaminobenzoic acid; 4 palmitoylaminophenol; acetic acid; amide; bacterium lipopolysaccharide; carrageenan; palmitic acid derivative; paracetamol; soybean oil; unclassified drug, analgesia; animal experiment; animal model; antiinflammatory activity; antipyretic activity; article; carbon nuclear magnetic resonance; chemical modification; controlled study; drug activity; drug potency; drug safety; drug screening; drug structure; drug synthesis; edema; female; fever; hot plate test; hyperalgesia; infrared spectroscopy; male; melting point; mouse; nonhuman; proton nuclear magnetic resonance; single drug dose; writhing test
Subjects: Faculty of Science > Environmental and Biological Sciences > Biochemistry
Faculty of Science > Pure Sciences > Chemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Chemistry
Jnana Bharathi / Central College Campus > Department of Biochemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 22 Mar 2016 09:24
Last Modified: 22 Mar 2016 09:24
URI: http://eprints-bangaloreuniversity.in/id/eprint/2180

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