Antibacterial and immuno-modulatory activity of ethanol extracts from Lespedeza sp. during Helicobacter pylori infections

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Yang, J.-K. and Yeo, H.-D. and Baik, S.-C. and Jung, J.-Y. and Kim, B.-M. and Jeong, M.-J. and Lee, C.-H. and Karigar, C.S. and Park, H.-M. and Choi, M.-S. (2010) Antibacterial and immuno-modulatory activity of ethanol extracts from Lespedeza sp. during Helicobacter pylori infections. Biotechnology and Bioprocess Engineering, 15 (6). pp. 1077-1083. ISSN 1976-3816

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Official URL: https://doi.org/10.1007/s12257-009-3115-z

Abstract

Chemical therapeutics targeted against H. pylori may lead to host toxicity and pathogen eradication failures. In this study, ethanolic extracts from five Lespedeza sp. plants were shown to inhibit the gastric-pathogen H. pylori and to modulate cytokine production. Disc agar diffusion assays showed that Lespedeza sp. ethanol extracts possess potent anti-H. pylori activity. Among the five plant extracts, the extracts from L. cyrtobotrya demonstrated the highest anti-H. pylori effect. The growth inhibitory effect against H. pylori was initiated after six h of treatment with plant extracts and the effect remained for a continuous period of 48 h. Incubation of the gastric cells infected with H. pylori with 1.25 to 50 mg/mL of sp. plant extracts resulted in a reduction of the production of cytokine IL-8. The plant ethanol extracts generally had little influence on AGS cell viability, indicating their safety for the treatment of bacterial infections. Three active fractions of L. cyrtobotrya also demonstrated similar anti-H. pylori and immuno-modulatory effects. Taken together, these results provide evidence that Lespedeza sp. plant extracts might be potential sources of new host friendly anti-H. pylori agents. © 2010 The Korean Society for Biotechnology and Bioengineering and Springer-Verlag.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Anti-bacterial activity; cell viability; Helicobacter pylori; human gastric epithelial cells; IL-8; Lespedeza sp., Cells; Ethanol, Plant extracts, alcohol; antiinfective agent; immunomodulating agent; interleukin 8; Lespedeza bicolor extract; Lespedeza cuneata extract; Lespedeza cyrtobotrya extract; Lespedeza maximowiczii extract; Lespedeza thubergii extract; plant extract; unclassified drug, antibacterial activity; article; bacterial growth; bacterium culture; carcinoma cell; cell viability; controlled study; cytokine production; drug cytotoxicity; drug potency; epithelium cell; growth inhibition; Helicobacter infection; Helicobacter pylori; human; human cell; immunomodulation; Lespedeza bicolor; lespedeza cuneata; Lespedeza cyrtobotrya; Lespedeza maximowiczii; Lespedeza thubergii; medicinal plant; nonhuman, Bacteria (microorganisms); Helicobacter pylori; Lespedeza; Lespedeza cyrtobotrya
Subjects: Faculty of Science > Environmental and Biological Sciences > Biochemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Biochemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 17 Mar 2016 06:05
Last Modified: 17 Mar 2016 06:05
URI: http://eprints-bangaloreuniversity.in/id/eprint/2076

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