Aging brain: Prevention of oxidative stress by vitamin E and exercise


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Asha Devi, S. (2009) Aging brain: Prevention of oxidative stress by vitamin E and exercise. TheScientificWorldJournal, 9. pp. 366-372. ISSN 1537-744X


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With aging, the brain undergoes neuronal loss in many areas. Although the loss of cells in the cerebral cortex, in particular the frontal cortex, has been recognized with aging, the influence of synaptic losses has a larger impact on cognitive decline. Much of the recent research on animals, as well as humans, has been aimed at slowing the cognitive decline through enrichment, and it has been found that the key factors are antioxidants and exercise. Several reports support the concept that regular supplementation of vitamin E and physical activity from as early as middle age can slow the cognitive decline observed during the later years. A few studies have also suggested that exercise is analogous to acetylcholine esterase inhibitors that are also used extensively to treat cognitive impairment and dementia in Alzheimer's disease. In addition, reports also support that vitamin E and exercise may act synergistically to overcome free radical injury and oxidative stress in the aging brain. ©2009 with author. Published by TheScientificWorld.

Item Type: Article
Additional Information: cited By 20
Uncontrolled Keywords: alpha tocopherol; ascorbic acid; cholinesterase inhibitor; free radical; nicotine; pilocarpine; trolox C; alpha tocopherol; antioxidant; hydrogen peroxide, aging; Alzheimer disease; antioxidant activity; brain; cognitive defect; drug half life; drug mechanism; drug potentiation; drug retention; drug uptake; exercise; human; neuroprotection; nonhuman; oxidative stress; short survey; unspecified side effect; vitamin supplementation; animal; cognition; drug effect; metabolism; physiology; review, Animalia, Aging; Animals; Antioxidants; Brain; Cognition; Exercise; Humans; Hydrogen Peroxide; Oxidative Stress; Vitamin E
Subjects: Faculty of Science > Environmental and Biological Sciences > Zoology
Divisions: Jnana Bharathi / Central College Campus > Department of Zoology
Depositing User: Mr. Kirana Kumar D
Date Deposited: 23 Mar 2016 10:42
Last Modified: 23 Mar 2016 10:42

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