Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures

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Kang, S.-M. and Min, J.-Y. and Kim, Y.-D. and Park, D.-J. and Jung, H.-N. and Karigar, C.S. and Ha, Y.-L. and Kim, S.-W. and Choi, M.-S. (2006) Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures. Journal of Biotechnology, 123 (1). pp. 85-92. ISSN 0168-1656

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Official URL: https://doi.org/10.1016/j.jbiotec.2005.10.021

Abstract

The effect of precursor feeding on the production of bilobalide and ginkgolides was studied with suspension cell cultures of Ginkgo biloba. The precursors greatly influenced the productivity of bilobalide and ginkgolides. Precursor supplementation increased the accumulation of both bilobalide and ginkgolides, and with positive effect on cell growth. The GA accumulation by cell cultures was influenced by precursors upstream in the metabolism, whereas the BB accumulation was under the influence of downstream precursors of the terpenoid biosynthetic pathway. Furthermore, precursor feeding modified the ratios of the BB, GA and GB in cells and cell cultures of G. biloba. The studies also aid in understanding effect of precursor feeding on the bilobalide and ginkgolides biosynthetic pathway. © 2005 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: cited By 16
Uncontrolled Keywords: Biosynthesis; Cells; Growth kinetics; Metabolism; Plants (botany), Bilobalide; Ginkgo biloba; Ginkgolides; MEP pathway; Mevalonate pathway, Cell culture, bilobalide; ginkgolide A; ginkgolide B; terpenoid, article; cell growth; cell metabolism; chemical modification; comprehension; controlled study; drug accumulation; drug synthesis; feeding; Ginkgo biloba; nonhuman; precursor; priority journal; supplementation; suspension cell culture, Bilobalides; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Ginkgo biloba; Ginkgolides; Terpenes, Ginkgo biloba
Subjects: Faculty of Science > Environmental and Biological Sciences > Biochemistry
Divisions: Jnana Bharathi / Central College Campus > Department of Biochemistry
Depositing User: Mr. Kirana Kumar D
Date Deposited: 24 Feb 2016 06:19
Last Modified: 24 Feb 2016 06:19
URI: http://eprints-bangaloreuniversity.in/id/eprint/1444

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